Beyond Gut Health: The Multifaceted Benefits of Healthmasters’ GHI Cleanse
Healthmasters’ GHI Cleanse is more than a gut health supplement; it epitomizes a holistic approach to well-being. This blend of thoughtful ingredients aims to support gut health and tackle inflammation naturally, promoting overall vitality.
Free of Allergens
Healthmasters’ GHI Cleanse product was developed with everyone in mind. Nowadays, it is common for most people to have an allergy or intolerance to something. Healthmasters’ GHI Cleanse excludes the most common allergens, including animal products, dairy, egg, fish, gluten, GMOs, peanuts, shellfish, soy, tree nuts, wheat, and yeast. Healthmasters’ GHI Cleanse contains plant-derived stevia as its primary sweetener, boasting only 5 grams of sugar per serving.
Protein
Notably, some people who want a regular protein powder but want to avoid dairy-derived protein drinks turn to Healthmasters’ GHI Cleanse because one serving contains 26 grams of protein per serving.
Notably, Healthmasters’ GHI Cleanse contains 26 grams of protein per serving, featuring a proprietary blend of pea protein isolate and rice protein concentrate, along with L-glutamine, glycine, and taurine, to support healthy protein synthesis, making it perfect for people who want a non-dairy-derived protein supplement.
Healthmasters’ GHI Cleanse is commonly used as a meal replacement because of its high potency and highly absorbable protein content. Most users will use Healthmasters’ GHI Cleanse to alleviate cravings and hunger between meals or even as a meal entirely on its own.
L-glutamine
Healthmasters’ GHI Cleanse contains L-glutamine, also referred to as Glutamine. This amino acid is one of the most abundant amino acids in the body and is involved in more metabolic processes than any other amino acid [1]. In a 2021 study, researchers conducted a systematic review and meta-analysis of controlled trials to investigate the effect of glutamine supplementation on fasting plasma glucose and inflammatory markers [2]. They concluded that glutamine supplementation might positively affect fasting plasma glucose and C-reactive protein, which is an inflammatory marker [2].
There is also research to support that glutamine supplementation may help manage the symptoms of irritable bowel disease, commonly known as IBS.
For example, in another 2021 study, researchers noted that therapeutic strategies for IBS are not yet well-established, so they conducted a “randomized, double-blind, placebo-controlled clinical trial” where they had two groups, both of which followed a low FODMAP diet – a specific restrictive diet that eliminates many inflammatory foods like wheat and dairy – but one group supplemented their diets with Glutamine and the other with a placebo [3]. At the end of the 6-week study, the researchers found that the glutamine group had “significant changes in total IBS-severity score, dissatisfaction of bowel habit, and interference with community function” [3].
Further, research shows that Glutamine is crucial in healthy intestinal cell proliferation, gut barrier integrity, immune function, and routine tissue healing [4] [5].
Ginger
Healthmasters' GHI Cleanse also contains ginger, another natural compound that has been highly studied to help lower inflammation in the body [6]. A 2022 study noted that many diseases, including ulcerative colitis, Crohn’s disease, rheumatoid arthritis, psoriasis, and lupus, have one characteristic in common: they are all inflammatory diseases [7]. The researchers found that, generally, many bioactive compounds in ginger can help reduce inflammation due to the compounds’ effect on inflammatory processes and their signaling pathways [7].
In another study, researchers investigated the effect of ginger extract on adiposity gain, an indicator of positive energy balance and metabolic and inflammatory disturbances caused by a high-refined carbohydrate (HC) diet in mice [8]. They stated, “Our findings indicate that high doses of ginger extracts prevent the increase of adiposity induced by HC diet, improves lipid profile, and promotes a decrease of inflammatory markers in mice” [8].
Flaxseed
Healthmasters’ GHI Cleanse also contains an organic flaxseed complex, which supports antioxidant activity and provides lignans, soluble fiber, and omega-3 and omega-6 essential fatty acids [9].
In a 2021 study, researchers investigated the effect of flaxseed on clinical biomarkers, quality of life, and disease activity in patients with ulcerative colitis by conducting an open-labeled, randomized controlled trial [10]. They found that flaxseed, both grounded flaxseed and flaxseed oil, attenuated systemic inflammation and improved disease severity in patients with ulcerative colitis, noting that patients’ quality of life was significantly increased in the flaxseed groups compared with the control group [10]. Other studies have also found that flaxseed supports lowered inflammation levels and markers [11] [12].
Detoxification Support
When people hear “green tea,” most think of caffeine or a coffee alternative. However, when formulating Healthmasters’ GHI Cleanse, we included a specific Green Tea Aqueous Extract – while maintaining a minimal amount of caffine so that the powder can be taken at anytime, day or night – with a high percentage of polyphenols, catechins, and EGCG (epigallocatechin gallate). We will take these in turn.
First, polyphenols are a category of plant compounds thought to boost digestion and brain health and protect against heart disease, type-2 diabetes, and possibly even certain cancers. When people want to integrate polyphenols into their diet, they most commonly turn to dark chocolate, tea, and berries. However, there are many plant-derived foods rich in polyphenols.
In general, polyphenols may benefit digestion by promoting beneficial gut bacteria while fending off harmful ones [13] [14]. This characteristic has been explicitly shown for polyphenol-rich tea extracts, which can encourage the growth of beneficial bifidobacteria [15].
Indeed, green tea polyphenols may help fight harmful bacteria, including C. difficile, E. Coli, and Salmonella, and improve symptoms of peptic ulcer disease (PUD) and inflammatory bowel disease (IBD) [16] [17].
Second, catechins are a type of dietary antioxidant compound [18]. Catechins act as an antioxidant and appear to act as a phase I and phase II detoxification [18].
In one study involving green tea catechin and aged mice, researchers acknowledged that daily consumption of green tea catechin “prevented memory regression and DNA oxidative damage in [the] mice” [19].
Although the researchers acknowledged that in their study, green tea catechin did not extend the lifetime in their mice, their “findings suggest that continued intake of [green tea catechin] might promote healthy aging of the brain in older persons” [19].
Third, EGCG is a type of catechin. Research suggests that EGCG may reduce inflammation and prevent certain chronic conditions, including heart disease, diabetes, and some cancers [20] [21].
In another animal study involving rats, researchers investigated the protective effects of green tea and EGCG on alleviating BPA-induced metabolic disorders [22]. BPA, or Bisphenol A, is a toxic chemical used in plastic that is extremely hard to avoid in modern life [23] [24]. In their study, numerous biomarkers were tracked and analyzed, including cholesterol, various liver enzymes, and blood pressure.
The researchers stated, “These findings indicate that green tea extract and EGCG can be effective in preventing or reducing metabolic disorders induced by BPA, linked to their antioxidant and anti-inflammatory activity, regulating the metabolism of lipids, and improving insulin signaling pathways” [22].
Overall, green tea, with its numerous compounds, has illustrated its ability to ameliorate oxidative stress in older people [25], athletes [26], and obese and hypertensive people [27].
Antioxidant Support and Cytokine Balance
We have already discussed how Green Tea operates as an antioxidant. Still, Healthmasters’ GHI Cleanse also contains additional bioflavonoids, quercetin, rutin, and curcumin. These compounds have been shown to support antioxidant activity, counter free radicals, and support healthy eicosanoid and cytokine metabolism [28] [29].
Bioflavonoids are a type of antioxidant and have been studied for their antioxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties coupled with their capacity to modulate critical cellular enzyme function [30].
Quercetin is a type of flavonoid. In a 2018 study, researchers conducted a meta-analysis of the association between the intake of dietary flavonoids and the risk of colorectal cancer. They examined 12 studies involving 17,481 cases and 740,859 controls. They noted that the high intake of flavanols may decrease the risk of colon cancer and also found that the data suggested that the high intake of flavanols, such as quercetin, may reduce the risk of colon cancer [31].
Curcumin is another type of flavonoid and polyphenol. Curcumin is commonly derived from turmeric and is a type of polyphenol. Curcumin has been shown to have a broad range of benefits, including antioxidant and anti-inflammatory properties, beneficial for arthritis and metabolic syndrome, and, in general, promotes overall health, as noted by a 2017 research review [32].
Curcumin has also been demonstrated in dozens of animal and in vivo studies to be beneficial for liver health, especially regarding preventing drug-induced and chemically-induced liver damage.
For example, a 2004 animal study found that curcumin attenuated alcohol toxicity [33]. A 2008 animal study showed that curcumin had a protective effect against nicotine-induced genotoxicity on rat livers and protected against DNA damage [34]. A 2000 animal study found curcumin prevented chemically induced liver cancer [35].
These compounds may also support healthy cytokine regulation and help prevent a cytokine storm. A cytokine storm is an immune system overreaction to something it senses as threatening. During this immune reaction, the body releases too many small proteins called cytokines that promote inflammation and activate other immune cells.
Indeed, curcumin is such a potent compound for supporting proper cytokine release that researchers have investigated its use for COVID-19 and Ebola and found beneficial results [36] [37].
Vitamins and Minerals
Healthmasters’ GHI Cleanse also contains a full array of bioavailable and chelated vitamins and minerals that help support healthy nutrient levels and optimal antioxidant and anti-inflammatory support. Its goal is to provide a base level of essential nutrients.
Starting with its B Vitamins, Healthmasters’ GHI Cleanse contains the active, bioavailable form of B6, B9, and B12, as pyridoxal-5’-phosphate, 5-methyltetrahydrofolate, and methylcobalamin, respectively.
Vitamin B6 is a coenzyme that catalyzes over 150 enzymes that regulate the metabolism and synthesis of proteins, carbohydrates, lipids, heme, and important bioactive metabolites [38].
A study published in Nature, a renowned medical journal, investigated whether Vitamin B6 supplementation had a beneficial effect on inflammatory and immune responses in patients with rheumatoid arthritis (RA) [39]. At the end of the 12-week study, in comparison to the placebo group, the researchers concluded, “A large dose of [B6 supplementation] suppressed pro-inflammatory cytokines . . . in patients with RA” [39]. Other researchers have also noted this effect [40].
Importantly, however, it is essential to note that the patients in the Nature study received 100mg/day of B6. In contrast, while Healthmasters’ GHI Cleanse contains 5mg/serving, Healthmasters' Coticare B5 B6 includes 75mg/serving for those who want an extra B6 boost.
Healthmasters’ GHI Cleanse also contains a spectrum of chelated minerals, including Magnesium, Zinc, Selenium, Calcium, Chromium, and Molybdenum.
Research supports that chelated minerals have a greater absorption rate and bioavailability than their cheaper, non-chelated counterparts. This is because, in general, raw minerals are challenging to absorb. Still, chelated minerals are minerals that are bound to an amino acid, typically glycinate or lysine, have a greater absorption rate, and are considered to be more stable [41] [42] [43] [44].
To sum it up, Healthmasters’ GHI Cleanse is an allergen-friendly formulation, curated with pinpointed ingredients to lower inflammation in the body, support optimal detoxification, and provide a baseline of nutritional supplementation, all while being a viable and tasty meal replacement.
If you have any questions about Healthmasters' GHI Cleanse, please feel free to call our office at 800.726.1834.
References:
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266414/
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053267/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716871/
[4] https://pubmed.ncbi.nlm.nih.gov/2119461/
[5] https://pubmed.ncbi.nlm.nih.gov/2080048/
[6] https://pubmed.ncbi.nlm.nih.gov/16709450/
[7] https://pubmed.ncbi.nlm.nih.gov/36364048/
[8] https://pubmed.ncbi.nlm.nih.gov/30362875/
[9] https://pubmed.ncbi.nlm.nih.gov/20003621/
[10] https://pubmed.ncbi.nlm.nih.gov/33482045/
[11] https://www.ncbi.nlm.nih.gov/pubmed/31739218
[12] https://www.ncbi.nlm.nih.gov/pubmed/33183549
[13] https://pubmed.ncbi.nlm.nih.gov/19914380/
[14] https://pubmed.ncbi.nlm.nih.gov/25802870/
[15] https://www.ncbi.nlm.nih.gov/pubmed/16962743
[16] https://www.ncbi.nlm.nih.gov/pubmed/29063625
[17] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216723/
[18] https://pubmed.ncbi.nlm.nih.gov/20116658/
[19] https://pubmed.ncbi.nlm.nih.gov/16957869/
[20] https://pubmed.ncbi.nlm.nih.gov/24494192/
[21] https://www.ncbi.nlm.nih.gov/pubmed/20716914
[22] https://pubmed.ncbi.nlm.nih.gov/34607205/
[23] https://healthmasters.com/reasons-avoid-bpa-and-bps-plastics
[24] https://healthmasters.com/five-common-household-chemicals-are-toxic
[25] http://www.ncbi.nlm.nih.gov/pubmed/27142448
[26] http://www.ncbi.nlm.nih.gov/pubmed/27736246
[27] http://www.ncbi.nlm.nih.gov/pubmed/22749178
[28] https://pubmed.ncbi.nlm.nih.gov/18321868/
[29] https://pubmed.ncbi.nlm.nih.gov/17431769/
[30] https://pubmed.ncbi.nlm.nih.gov/28620474/
[31] http://www.ncbi.nlm.nih.gov/pubmed/30041489
[32] https://www.ncbi.nlm.nih.gov/pubmed/29065496
[33] https://www.ncbi.nlm.nih.gov/pubmed/15367386
[34] https://www.ncbi.nlm.nih.gov/pubmed/18508046
[35] https://www.ncbi.nlm.nih.gov/pubmed/11038236
[36] http://www.ncbi.nlm.nih.gov/pubmed/36721816
[37] http://www.ncbi.nlm.nih.gov/pubmed/25600522
[38] https://pubmed.ncbi.nlm.nih.gov/29477221/
[39] https://www.nature.com/articles/ejcn2010107
[40] https://arthritis-research.biomedcentral.com/articles/10.1186/ar1821
[41] https://www.ncbi.nlm.nih.gov/pubmed/24259556
[42] https://www.ncbi.nlm.nih.gov/pubmed/31330811
[43] https://www.ncbi.nlm.nih.gov/pubmed/31453173
[44] https://www.ncbi.nlm.nih.gov/pubmed/29397180
*These statements have not been evaluated by the Food and Drug Administration. Healthmasters' GHI Cleanse is not intended to diagnose, treat, cure, or prevent any disease.
